Nicotine Warning

The Effects of Nicotine

"The main adverse effect of nicotine is addiction, which sustains tobacco use. Because most smokers are nicotine-dependent, they continue to expose themselves to toxic elements from tobacco. Tobacco, not nicotine, is responsible for most of the adverse health effects."

Nicotine is a highly addictive drug, as addictive as heroin or cocaine when delivered by means of tobacco products (USDHHS, 1988). Nicotine is used by tobacco users to modulate mood and arousal, as well as for pleasure. Upon cessation of tobacco use, withdrawal symptoms develop, which are generally unpleasant and often disruptive to daily life. The addictive effect of nicotine (including conditioned reinforcement effects) sustains tobacco use. In the absence of nicotine, it is unlikely that sustained smoking behavior would be supported over the long-term. Conversely, nicotine-containing medications (termed nicotine replacement therapy) can be used instead of tobacco to aid quitting. The addiction risk of nicotine in medications has proved to be very low compared to the risk posed by tobacco products (USDHHS, 1998; Benowitz, 1998; Royal College of Physicians, 2008) probably because nicotine medications produce a slow onset of very low levels of nicotine. While people use tobacco for the effects of nicotine, they suffer adverse health consequences, mainly from damage caused by tar, oxidizing chemicals, carbon monoxide and other constituents of tobacco or tobacco smoke (Smith et al., 2003; Surgeon General's Report 2010).

In other words, it is the delivery system, not the addictive drug, which is responsible for the vast majority of tobacco-related disease. More detailed information on the effects of nicotine on cardiovascular disease and pregnancy are discussed in the commentaries on other key findings in the section.


These products can expose you to chemicals including acetaldehyde and/or formaldehyde, which are known to the State of California to cause cancer, and nicotine, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to

This website contains adult material and is only suitable for adults. Purchase here only if it is legal to buy these products in your city, state, and country. These products are NOT components of tobacco products and are NOT intended to be used in the consumption of tobacco products. All vegetable glycerin (VG) / propylene glycol (PG) ratios given are approximate. High VG and Max VG e-liquids are designed for dripping atomizers, and will not perform well in many vape tanks. Nic Salts liquids are designed to be used in refillable vape pod systems only. Bottles, packaging, and labels change frequently. The item you receive, while authentic, may not be the exact same as pictured. Manufacturers are required to provide proof of PMTA filing with the FDA. If an item shows "unavailable," it means we have not received proof of filing.

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